THE GLUCOCORTICOID RECEPTOR IN CARDIOVASCULAR HEALTH AND DISEASE

The Glucocorticoid Receptor in Cardiovascular Health and Disease

The glucocorticoid receptor is a member of the nuclear receptor family that controls many distinct gene networks, governing various aspects of development, metabolism, inflammation, and the stress response, as well as other key biological processes in the cardiovascular system.Recently, research in both animal models and humans has begun to unravel

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Estimating and forecasting suppressed electricity demand in Ghana under climate change, the informal economy and sector inefficiencies

Suppressed demand arises from inadequate energy access, resulting in unmet basic needs.Therefore, this study investigates the impact of the informal economy, rising temperatures, and electricity transmission losses on suppressed demand in Ghana from 2000 to 2020, using a quantile autoregressive distributed lag (QARDL) approach.The study forecasts s

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A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.

Iron is an essential cofactor, but it is also toxic at high levels.In Schizosaccharomyces pombe, the sensor glutaredoxin Grx4 guides the activity of the repressors Php4 and Fep1 to mediate a complex transcriptional response to iron deprivation: activation of Php4 and inactivation of Fep1 leads to inhibition of iron usage/storage, and to promotion o

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